The Guardian

Optogenetic therapy, based on Nobel prize-winning science, involves turning nerve cells on and off using light A type of gene therapy based on Nobel prize-winning science is safe and can partly restore sight in blind people, researchers have revealed.

Maricarmen’s eviction from Madrid apartment after over seven decades set off wave of protests against housing crisis ‘Now is the moment’: housing activists at Madrid encampment pin wary hopes on Spain’s early election María del Carmen Abascal, the 87-year…

‘Transparent information sharing’ from Moscow is required to conduct full risk assessment, UN agency says The World Health Organization has said it does not have the “full picture” from Russia following the suspected death from plague last week of a 28-ye…

Authorities say they arrested an 18-year-old who was planning a shooting attack at the Mall of America FBI officials stopped a potential terrorist attack on the Mall of America in Bloomington, Minnesota, authorities announced Wednesday.

Bernadette Greene-Placentia says she is sharing her story in order to fight for victims of sexual assault This article contains graphic descriptions of sexual assault.

Verdict has been a long time coming and the Southampton head coach has recaptured hearts and minds at St Mary’s “Hi Tonda, are you a cheat?”

Group’s fighters hit key airport in Aden with explosive moments before plane from Cairo was due to land Houthi forces appeared to be making slow advances on Wednesday in south-west Yemen, approaching the city of Taiz and firing a missile and an explosive…

Lithuania and Canada were also pressured to withdraw, and days before #Disinfo2026, logos were wiped off website The Trump administration pressured multiple countries to withdraw their sponsorship of a leading European conference on disinformation, with C…

Pentagon chief tries to play down problems onboard carrier as it returns to dock after 260 days at sea without port call Pete Hegseth, the US defense secretary, told service members on the USS Abraham Lincoln on Wednesday that their deployment “wasn’t eas…

Judge tells Tennessee officials all items in execution room must be saved as Pike remains restrained in hospital bed A judge ordered Tennessee officials on Wednesday to preserve all evidence related to the botched execution attempt on convicted murderer C…

Legislation an effort by ruling Liberals to address growing clash over who has access to doctor-assisted death Canada’s federal government said Wednesday it would advance legislation to prevent people whose sole health condition is mental illness from acc…

Events were held in Israel and around the world to mark the third anniversary of the attacks led by Hamas on kibbutzim, border towns, military bases and a music festival in Israel, in which 1,209 people were killed and 251 hostages were taken Continue rea…

Head coach pleased ‘everyone bought in’ to new ideas Jarell Quansah says: ‘We can really dominate teams’ Thomas Tuchel believes England have unlocked a new level after moving forward with his tactical tweaks in the opening Nations League fixtures.

DNA analysis of oldest living land animal reveal patterns on genes that appear to protect functioning of mitochondria The ancient quest to extend human lifespan has received a boost after scientists analysed the genetic code of the world’s oldest living l…

While it’s full steam ahead for Alex Scott, Lewis Hall and Myles Lewis-Skelly, others look likely to be left behind Thomas Tuchel’s original idea had been for continuity.

Donald Trump’s unpopularity and the economic struggles of voters have boosted Democrats.

Two-time major winner is reportedly owed over £100m Tour filed for bankruptcy after Saudi funding withdrawn Jon Rahm is to quit LIV Golf due to the “unacceptable” terms offered for the proposed relaunch of the breakaway series.

Organisations honour those who died three years ago as Andy Burnham says government stands with British Jews British Jewish organisations gathered in central London on Wednesday for a vigil honouring victims of the 7 October attacks in Israel, after a day…

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Technical director held court at club’s training base, comparing rugby to winemaking and claiming interviews ‘steal my joy’ Brendan Venter began his long-awaited public appearance with head bowed, uttering one-word answers and with a general demeanour he…

Christa Pike, a death row inmate who survived the state of Tennessee’s attempt to execute her last week, is conscious and speaking.

August Hanning, 80, appears before judge after being accused of treason and espionage on behalf of foreign state A formal arrest warrant has been issued against Germany’s former top spy, with a judge ordering him to be held in pre-trial detention, a day a…

Jorge Messi wanted his country to fall in love with his son.

TaxWatch research contradicts claims about David Reuben’s departure and questions stories of super-rich exodus Apparent exodus of super-rich suggests UK is no longer billionaires’ playground When the Sunday Times broke the news that David Reuben, one of t…

Texas attorney general acknowledged affordability was his party’s ‘biggest problem’ heading into the midterms US politics live – latest updates Ken Paxton, the Texas attorney general running as the Republican candidate in a competitive Senate race, admitt…

Improvements to the car are paying off as the team look to lay the groundwork for renewed success next season The importance for Max Verstappen of emerging triumphant from the Bahrain Grand Prix in Malaysia was writ large in the Dutchman’s pleasure at fin…

Sales at one UK retailer are up 200%, thanks in part to young people rejecting the informal look adopted by their middle-aged bosses Name: Ties.

This year’s harvest is expected to be down 2% on mediocre 2025 yield, which was lowest in nearly 70 years France’s wine industry is facing a historic low harvest after the country was hit by a series of summer heatwaves.

Tennessee prisoner awake and speaking after surviving state’s attempt to execute her last Wednesday Christa Pike is conscious and speaking after botched execution attempt, lawyers say Tennessee’s top prison official is resigning following Christa Pike’s b…

Eckert was charged by FA with misconduct Southampton found to have spied on three opponents Southampton’s manager, Tonda Eckert, has been given a six-week suspended ban by the Football Association for his part in the Spygate scandal that landed the club w…

Former Selfridges owners buys UK high street institution from long-term backer Stefano Pessina The Canadian family that once owned Selfridges department store has bought UK pharmacy and beauty retailer Boots for $8.9bn (£6.74bn).

Sean Peers admits offence against woman who was drugged and attacked for more than two decades A man has pleaded guilty to sexually assaulting an unconscious woman, whose husband had drugged her and invited other men to abuse her.

We appear to be entering a new era, in which political desperation at home leads to increasingly unhinged threats abroad Donald Trump was in Nebraska on Monday, and though his long rally speech had elements of a performance, this was no Bruce Springsteen…

Chinstrap penguins on Zavodovski Island in Antarctica down by two-thirds since 2011, probably due to climate crisis The world’s largest penguin colony has declined by two-thirds since 2011, most likely because of the climate crisis, a study has revealed.

Sir James Goldsmith’s links to Hilton Head, South Carolina, adds to mystery of Jane Doe 4, who claimed she was abused by Epstein in the 1980s For Jeffrey Epstein, the billionaire Goldsmith family was a gateway to elite society and he wanted to be in their…

At Conservative conference, some worry about becoming a one-woman party, while others say party should thank their lucky stars they have her UK politics live – latest updates Kemi Badenoch has long said that the Conservatives were “under new management”,…

New ‘support and training centre’ prompts concern in region but China says it is ‘not directed at any third party’ Satellite images show attack jets stationed at a new overseas Chinese military facility in Laos, which opened last week and gives Beijing’s…

The big question facing Andy Burnham is not whether Brexit has harmed Britain, but if a rapidly changing Europe will keep the door open if the UK decides it wants back in • Don’t get This Is Europe delivered to your inbox?

Nothing compares to sport’s contrasts, and few are as stark as the exits of two defining icons of the modern football era.

A mix of natural disasters could all befall the state at once as it finds itself in the crosshairs of the climate phenomenon On a cloudless autumn afternoon, sunlight sparkled on the water that had quietly swallowed a busy intersection to the north of San…

From Carrie’s bullies to Cathy Ames, sympathetic backstories have made villains boring.

After a surprise first-round victory, critics suggest son of disgraced ex-president could seek to continue his father’s authoritarian rule Flávio’s surprise first-round win highlights rapid rise of Brazil’s House of Bolsonaro Flávio Bolsonaro, the far-rig…

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Nearly 460 schools are affected by continuing protests today, just over a half of those that joined the ‘day of mobilisation’ yesterday We are getting reports of a knife attack at a vocational school in Ostrołęka, Poland, which left at least seven people…

After a life-threatening infection, the Australian singer-songwriter has rebuilt her relationship with music – and her third album ‘sounds nothing like the last’ The illness that almost killed Gretta Ray announced itself slowly.

Andrew Garfield’s fictional ploughman joins the historical heroes of the 1381 Peasants’ Revolt in a dirt-caked, docudrama-style film with disconcertingly silly moments Paul Greengrass has in fact already made his “uprising” film: United 93, the gut-wrench…

Exclusive: The rough sleeper with a ‘massive personality’ now lies buried in a plot with four strangers, despite being well known to local homelessness services Find more from the Unmarked graves investigation here Get our breaking news email, free app or…

Rightly described as ‘Gremlins meets Hot Fuzz’, this fun series has the high-spirit and gusto one hopes for in a show about evil killer gnomes One can never trust marketing materials to accurately describe a movie or TV series, but I’m pleased to report t…

From Day of the Dead to Samhain, celebrating autumn is centuries old.

Forced closure marks low point in UK-Israeli relations, with reports UK is considering retaliatory expulsion of Israeli diplomats from London Israel marks three years since 7 October attack – live The UK consulate in East Jerusalem gave few signs that it…