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  1. President Xi Jinping and President Donald Trump at the White House on September 24, 2026 in Washington, DC.

  2. —Viktoriya Skorikova—Getty Images The field of weight-loss drugs is moving more quickly than ever since medications that mimic GLP-1, a type of peptide hormone in the gut, hit the market to treat weight issues and diabetes.

  3. Jane Goodall during an interview in New York City on Oct. 1, 2023.

  4. —Tim Robberts—Getty Images My interest in venture capital (VC) began long before I ever imagined building an actual venture capital fund.

  5. Defense Secretary Pete Hegseth testifies during a Senate Appropriations Committee hearing in the Dirksen Senate Office Building on Capitol Hill in Washington, D.C., on July 21, 2026.

  6. —Molly Cranna for TIME Frailty is more than just slowing down a little with age.

  7. —Photo-Illustration by Chloe Dowling for TIME (Source Image: Halfpoint Images/Getty Images) When your kid comes home from school and says they hate their stomach, that nobody wants to be their friend because they’re “fat,” or that everyone in their class…

  8. Javier Milei takes part in a discussion about economies at an event in New York on Sept. 24, 2026.

  9. President Donald Trump in the Oval Office at the White House on September 28, 2026.

  10. Passengers board a Flydubai flight, bound for Dubai, before taking off from Ben Gurion Airport near Tel Aviv on Sept. 30, 2026.

  11. —Maskot—Getty Images For decades, women’s sports were asked to prove themselves.

  12. —Westend61—Getty Images This fall in the U.S., as kids settle into a new school year, measles is spreading at a level not seen in 35 years.

  13. —Art Direction and Set Art by Jana Frost for TIME; Photography by Stefano Giuliano for TIME It’s been a while since South London singer Raye was a supporting act for another artist.

  14. Arch Manning

    —Alex Slitz—Getty Images

  15. Sasha Gordon

    —Jay Kolsch

  16. —Courtesy Anna Sokol

  17. —Cristián Carvallo—El Mercurio

  18. —Alexey Yurenev—Bloomberg/Getty Images

  19. Joey King

    —Swan Gallet—WWD/Getty Images

  20. —Erik Carter—AUGUST

  21. Paapa Essiedu

    —Stuart Wilson—BAFTA/Getty Images

  22. —Big Event Media—Getty Images/HumanX Conference

  23. —UCS

  24. —TheStewartofNY—Getty Images

  25. —Gareth Cattermole—Getty Images for IMDb

  26. Sarah Pidgeon

    —Caroline Tompkins—The New York Times/Redux

  27. E.J. Lagasse

    —Daymon Gardner

  28. —Rahim Fortune

  29. Alex Consani

    —Neilson Barnard—MG26/Getty Images/The Met Museum/Vogue

  30. —John Dorton—USSF/Getty Images

  31. Joshua Henry

    —Sara Krulwich—The New York Times/Redux

  32. Katie Dippold

    —Eric Charbonneau—Apple TV/Getty Images

  33. —Adam Hagy—NBAE/Getty Images

  34. Skye Duncan

    —Courtesy Global Designing Cities Initiative

  35. —Oli Scarff—AFP/Getty Images

  36. —Cibelle Levi

  37. —Paloma Laudet—AFP/Getty Images

  38. A panel of executives spoke on Tuesday at a TIME100 Talk titled "Built to Last: The Enduring Power of Iconic American Brands" about the ways in which their companies have been able to adapt and dominate their industries throughout the years.

  39. The exterior of the Eli Lilly and Company headquarters in Indianapolis on June 13, 2024.

  40. Visitors prepare to ride the X2 roller coaster at Six Flags Magic Mountain in Valencia, Calif., on April 20, 2015.

  41. Kari and Gina Bravata in Behind the Mirror —Courtesy of Hulu “There is the everyday nastiness baked into reality shows that manipulate cast members into bad-mouthing and backstabbing each other, and then there is The Swan.”

  42. American flags fly at the The White House on Aug. 12, 2026 in Washington, D.C.

  43. President Donald Trump arrives to speak during an event to unveil the new America.gov website at the Andrew W.

  44. Tom Cruise and Riz Ahmed —Warner Bros.

  45. ©ChrisChumbley —Getty Images From ambitious newcomers disrupting their industries to established businesses accelerating their growth, the fastest-growing companies in the U.S. stand out through innovation, resilience, and the ability to turn momentum into

  46. Smoke rises from the area surrounding Ali al-Tahir hill following an Israeli strike, on June 12, 2026, in Nabatieh, Lebanon.

  47. The Google homepage now has an AI Mode button instead of a Search button.

  48. —Photo-Illustration by TIME Your bucket list is probably full of big dreams: go sky-diving, learn to speak Italian, finally take that trip to see the northern lights.

  49. Sen.