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I’m relocating this blog to Substack: https://zachocean.substack.com/ Why?

What makes Forever Chemicals forever?

Protein Dojo is a platform for learning protein design by practicing with realistic drug targets and modern computational molecular design tools.

Chinese Peptides in Silicon Valley - NYTimes PeptiVerse: Peptide Property Prediction - Hugging Face The MPTP Story - J William Langston (MPTP and Parkinson’s) A Multimodal Sleep Foundation Model for Disease Predictions - Nature Medicine (code) NewLimit Up…

Not For Human Consumption - Vectorculture Ph.D.s Can’t Find Work as Boston’s Biotech Engine Sputters - WSJ Alignism - Sequence Alignment - hgbrian The Generative Geometric Turn in AI Drug Discovery - LiteFold A Visual Guide to Keytruda - Liam Bai Rebuild…

2025 LLM Year in Review - Karpathy Chemical Hygiene - Karpathy A Comprehensive Introduction to AI for Proteins - Tamarind Bio https://x.com/shelbynewsad/status/2003508957155844390 AI drug designer Insilico Medicine aims to generate $300M in Hong Kong IPO -

Aaron blotnick’s jpm week list: JPM Week 2025 Event List Using Claude Code for computational biology De novo design of luciferases using deep learning Latent X2 Technical Report Immune repertoire profiling for disease pathobiology China’s Biotech Is Cheap…

Sugars, ‘Gum,’ Stardust Found in NASA’s Asteroid Bennu Samples AI in biotech investor tweet thread: Jeffrey Low MD on X High throughput binder screening in 2 weeks for the adaptyv nipah virus competition: Nipah Binder Competition Submission 1 To Get More…

Periodic Table of Antibodies Computer Scientist’s Guide to Cell Biology Just know stuff, proteinML edition Retro bio clinical trial (1st one): ANZCTR Trial Registration

Boltzgen deep dive: Anatomy of BoltzGen Cradle Bio guy reading list: Just know stuff, proteinML edition Design comp (Ends December 1): Nipah Binder Competition IF1 Protein Controls Aging Rate Somatic mutations impose an entropic upper bound on human lifes…

From Lada Nuzhna’s trilly biotech post: Advancing gene-editing platforms to improve the viability of rare-disease therapeutics: key insights from a 2024 Scientific Exchange hosted by ARM, ISCT, and Danaher First-In-Human Therapy Stem Cell Dopaminergic Pro…

RFantibody, Github The Desci $50k

Chinese peptides, Everyone has a Chinese peptide dealer now More Chinese peptides, Tech bro’s manual for living forever Finnrick: Testing for Chinese peptides What should Finnrick test text?

Let’s implement some attention modules.

It’s not obvious to me prima facie how tensor.T would be expected to work for tensor shapes of more than 2d, i.e. len(tens.shape) > 2.

Accept the mission Be humble Don’t mourn your flaws and shortcomings Be thankful for what you have Be thankful for the opportunity Be courageous Be resilient Remember the why Resist short-term temptation Act with urgency, but be patient

Jensens’ inequality says that for convex function $f(x)$ and random variable $X$, $f(E[X]) \le E[f(x)]$.

Variational (as in variational inference, variational autoencoder, etc) is an unintuitive term.

If you’re working in a project which relies on conda installs for system dependencies but you also want to use uv instead of pip for much faster python-only dependencies: You can create a new conda env the usual way (conda create -n whatever), then pip in…

Google released an API for their 2-way dialog model, the same technology that powers the podcast generation feature in NotebookLM.

Sometimes it feels like superhuman text to speech (and generative audio in general) is solved.

My experience with startups is that joy scales with growth rate and misery scales with headcount.

How to reach me: X (formerly Twitter) LinkedIn Email Substack

Now is a good time to start a service business.

Today, a short tale of fun mystery-solving.

A small, cool fact about SQLite is that its columns are flexibly typed.

A list of useful or entertaining allegories about work.

Zach Wener is a software engineer and writer.

Three months ago, the college fiscal crisis was a fringe issue.

I recently came across a gem of an idea in a Douglas Crockford interview with Peter Seibel, from Seibel’s Coders at Work.

I’ve got a proposal for an alternative to the dreaded technical interview loop that could make life easier, better and cheaper for people and their companies.

So you want to putter around with some data using Jupyter Notebook, and you don’t want to be limited by your local machine’s specs or have your laptop fan sounding like a jet engine.