Fight Aging!

Peroxisomes in cells are responsible for helping to maintain oxidative metabolism via making and removing hydrogen peroxide, but are also involved in numerous aspects of lipid metabolism, breaking down or converting various lipids necessary to cell functi…

Senescent cells accumulate with age, perhaps primarily because the aged immune system becomes less able to efficiently destroy senescent cells as it does in youth.

Partial epigenetic reprogramming involves exposing cells to some or all of the Yamanaka factors for a long enough period of time to reset epigenetic decorations on nuclear DNA and its supporting structures to a youthful state, but not so long as to risk d…

The gut microbiome changes with age, and evidence suggests that this provides a meaningful contribution to degeneration and disease.

The oldest land animal with an established age is an Aldabra giant tortoise, at 194 years.

Fight Aging!

Mediation analysis is a statistical technique can be used in an attempt to shed some light on why a correlation between two variables might exist, by involving a third variable that might be causative.

The aging of the immune system arises from the underlying causes of aging, but in and of itself causes significant further pathology.

Smaller dog breeds live for longer than larger dog breeds, which perhaps allows some insight into mechanisms of aging.

Animal studies suggest that the composition and activities of the gut microbiome are as influential on long-term health and the progression of degenerative aging as is the case for lifestyle choices such as degree of physical fitness and level of physical…

Dental follicle stem cells can be used as a basis for regenerative cell therapy in the treatment of periodontitis, the prevalent form of gum disease, and a condition that becomes more common with age.

Cancers are primarily age-related conditions for a range of reasons, such as the decline of the immune system's ability to find and destroy cancerous cells, a rising burden of senescent cells providing a more hospitable environment for cancerous growth, a…

The tissues of the mammalian body span a broad range of regenerative capacity, from the highly regenerative liver to the minimal regenerative capabilities of the brain and the heart.

Any sufficiently complex set of biological data that changes with age can be used as the basis for an aging clock.

Added to the growing list of specific ways in which the gut microbiome can contribute to degenerative aging, researchers here note that indole produced by gut microbiobes provokes a chain of events that worsens the maladaptive inflammatory immune response…

Cancer survivors who underwent chemotherapy or radiotherapy in the course of putting their cancer into remission have been shown to exhibit an increased burden of senescent cells relative to healthy peers.

The first human application of partial epigenetic reprogramming of aged tissues, using adeno-associated viral (AAV) vectors, was not in fact the first patient dosed in the recently launched Life Biosciences clinical trial for optic neuropathy.

AMPK is the target of a range of interventions known to modestly slow aging in short-lived species.

Hundreds of mitochondria in every cell work to produce adenosine triphosphate (ATP), a chemical energy store molecule needed to power cell activities.

The immune system of the brain and body are distinct from one another, separated by the blood-brain barrier that lines blood vessels passing through the central nervous system.

Researchers here discuss the chronic inflammation of aging as a contribution to the bidirectional relationship between the loss of bone mineral density leading to osteoporosis and neurodegenerative pathology leading to cognitive impairment.

An important goal in the research community is to build a robust measure of biological age, the burden of age-related damage and dysfunction contributing to disease and mortality, that can be used to rapidly assess the quality of any potential intervention

Any sufficiently complex biological data that changes with age can be used to construct an aging clock.

The antimicrobial drug K21 acts via disruption of bacterial membranes, but is also known to produce improved wound healing, which suggests the involvement of mechanisms other than antimicrobial activity.

Fight Aging!

Aging clocks have yet to fulfill their promise, which is to produce a robust measure of biological aging that can be used to rapidly assess the results of potential therapies to slow or reverse the progression of aging, such as via repair of underlying ce…

First generation stem cell therapies have become widespread; they are readily accessed in medical tourism clinics, and are also available for a range of issues in more regulated parts of the world.

The commensal microbes of the gut microbiome generate a range of metabolites that are beneficial or necessary to cell function.

The effects of calorie restriction and even larger effects of growth hormone receptor knockout on the lifespan of mice have proven to be hard to beat.

Why is the APOEε2 variant of the APOE gene associated with a lower risk of Alzheimer's disease and slightly longer life expectancy?

Given a wildly successful drug, the standard pharmaceutical industry playbook is to push as hard as possible to find new uses for that drug, an effort that will tend to increase publication on the topic in the academic literature.

An archly conservative viewpoint links establishment academia ("this thing you are doing has not yet been proven beyond all doubt to work") to the thought leadership of Big Pharma ("this thing you are doing has not yet been proven beyond all doubt to gene…

Mitochondrial transplantation as a form of therapy to improve mitochondrial function in aged tissues has barely started as a going concern, and only a few patients have been treated in early studies conducted to date.

It is well known that electromagnetic fields affect cellular biochemistry, but the interactions are complex enough that electromagnetic therapies have yet to emerge in any robust way.

Of the many varied approaches to mimic some of the beneficial metabolic response to calorie restriction, mTOR inhibition is arguably the most well studied.

Later stages of Alzheimer's disease and other tauopathies are characterized by the aggregation of altered tau protein, and a toxic surrounding biochemistry that provokes inflammation and destroys neurons.

Researchers here provide an initial proof of concept demonstration of a novel foundation for replacing lost visual capacity in cases of retinal degeneration, without addressing the underlying pathology that causes loss of function in photoreceptor cells.

PD-L1 found on the surface of cells is a well known immune checkpoint protein.

Researchers here provide a proof of concept for the use of Raman spectroscopy to non-invasively measure the burden of senescent cells in an imaged tissue.

One of the more interesting new concepts in aging research is that repeated activation of the DNA damage response may cause epigenetic changes in the management of nuclear DNA structure that are characteristic of aging.

Fight Aging!

Type 1 conventional dendritic cells are a subclass of dendritic cell known to be an important component of the immune response to pathogens and cancerous cells, particularly focused on stimulating the activity of cytotoxic T cells.

Suppression of cancer is a necessary component of species longevity, and finding out how exactly cancer incidence is in some cases dramatically reduced is one of the primary goals for the field of comparative biology.

Here find a small slice of programmed aging consideration focused on some of the changes in cognitive function that take place in later life.

It is well understood in the aging research community that the lack of a useful, consensus measure of biological age or pace of biological aging is a considerable hindrance to progress.

Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to the progression of aging and speci…

Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine triphosphate (ATP) to power the cell.

The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction.

Researchers here take a very broad tour of the established literature on the comparative biology of aging in long lived species of all sorts, picking from those that can live more than 250 years, whether plant or animal, and comparing reported differences…

Rationing of sugar in the United Kingdom in the years immediately following the Second World War forms a natural experiment in the long term effects of changes in human nutrition that can be explored in great detail given the establishment of the UK Bioba…