Fight Aging!

A range of gene therapies are presently available in the medical tourism community of clinics outside the US and Europe, largely originating with a small number of companies such as BioViva Sciences and Triple Helix Science.

Senescent cells accumulate with age, likely largely because the aging of the immune system slows down the clearance of senescent cells, but the relative importance of different contributions to the growing burden of senescence in aging tissues is an area…

Researchers here suggest yet another possible use for retinal imaging, in this case an assessment of the burden imposed on the central nervous system by atrial fibrillation in its early stages.

Like many age-related conditions, atherosclerosis is accelerated by the chronic inflammation of aging.

Every tissue in the body exchanges signals with every other tissue.

Researchers here process data from a longitudinal study of several thousand people to show that better cardiovascular heath in the early 40s correlates with better outcomes in later old age.

Fight Aging!

The major neurodegenerative conditions are characterized by pathology deriving from a small number of misfolded or otherwise altered proteins.

The research community is in the early stages of development of therapies for age-related neurodegeneration based on reprogramming the supporting glial cells of the brain to provoke transformation into neurons.

Atherosclerosis, the growth of fatty plaques in blood vessel walls, is the largest cause of human mortality.

PD-L1 and PD-L2 are components of immune checkpoints, widely expressed in tissues throughout the body.

Damage to nuclear DNA occurs constantly, and near all of it is immediately repaired.

Sports medicine is somewhat focused on specific functional aspects of health, and so it was probably inevitable that factions in that community found the measures of life span and even health span to be lacking.

A great deal of advocacy for the development of therapies to slow and reverse aging has moved on from a focus on reducing suffering.

Sarcopenia is the name given to severe age-related loss of muscle mass and strength.

Normal cell metabolism, particularly the activities of mitochondria, generates oxidizing molecules that react with proteins to disrupt their function.

A few species of hydra are immortal in their normal environmental conditions, meaning that function does not decline over time and mortality risk does not increase over time.

Persistent infections such as cytomegalovirus and other herpesviruses most likely accelerate aging, primarily via harmful effects on the immune system that lead to earlier immunosenescence and chronic inflammation than would otherwise be the case.

Cells become senescent constantly throughout life in response to various forms of damage and stress, ceasing replication and generating a potent mix of inflammatory signals.

Despite considerable and growing effort put towards the development of novel means to slow and reverse aging over the past thirty years, the longest lived laboratory mice remain those lineages first established in the 1990s with mutations that disable gro…

Researchers here run a much larger than usual mouse study to show a ~10% slowing of aging, depending on how one slices the data, in mice genetically engineered to exhibit a growth hormone mutation that changes the interaction of circulating growth hormone…

Researchers have been working towards practical approaches to inhibiting RUNX2 activity as a way to slow age-related loss of bone mineral density.

Fight Aging!

The immune systems of the body and brain are distinct and separate, or at least largely separate, influencing one another via signaling.

Atherosclerosis is the largest cause of human mortality, producing stroke and heart attack when fatty plaques obstructing arteries rupture.

Aging is a complex stochastic process of damage accumulation, shaped at the detail level by choices made, environments encountered, and the responses and interactions of countless cells.

Every field of specialist knowledge consists of a series of concentric circles, the greatest knowledge at the center, the scientists advancing the state of the art, and the least knowledge at the outskirts, the public at large.

Aging clocks built using machine learning techniques applied to biological data are colloquially said to measure biological age, or at least aspire to measure biological age.

The accumulation of senescent cells is an important contribution to degenerative aging; the inflammatory secretions of senescent cells actively degrade tissue structure and function.

Without careful study design, studies in which the use of GLP-1 receptor agonists such as semaglutide lowered calorie intake significantly via suppression of appetite might be expected to teach us little that we did not already know.

Past research has noted that socioeconomic status is a part of a web of correlations that include wealth, intelligence, education, lifestyle choices, and longevity.

Screening compound libraries for effects on aging in short-lived species has grown to become a significant area of interest in the aging research community.

At the high level, without delving into specific mechanisms, the consensus view on aging is that it exists in the shadow of natural selection.

One of the goals of the Dog Aging Project is to better establish that the characteristics of aging in dogs are close enough to the characteristics of aging in humans to make the results of interventions on dog life span relevant to the development of human