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  1. [Epistemic Status: Speculative unifying theory of biology.]

  2. This is a great and wonderful contribution and you seem really nice and I’d like to show some appreciation but your comment is so complete and flawless that I can’t think of anything intelligent to say so I guess I won’t respond at all, sorry.

  3. (Inspired by a post from Eli Tyre.)

  4. Humans make carbon dioxide.

  5. To blog is to get dunked on.

  6. Is creatine a weird steroid-like hormone or drug?

  7. Pseudpocalypse

    Here’s a conjecture: If you put any significant amount of text on the internet under different names, those identities can be linked using only the text itself.

  8. If you read anything about health or longevity, you’ll soon find yourself in a world of hazard ratios.

  9. I write every word I post on this blog myself.

  10. For a while there, many people thought vitamin D was magical—that it could improve bones, the heart, infections, cancer, heart disease, longevity, even mental health.

  11. (Yes, but.)

  12. News from the world of real jobs: Apparently, sometime between 10 and 20 years ago, it became standard for people to communicate by sending slide decks around.

  13. This is an essay that recently appeared in Asterisk.

  14. In early January 2025, a family friend was over for lunch.

  15. Coding, math, whatever.

  16. EXHIBIT A Here is some text.

  17. 1.

  18. How heritable is hair color?

  19. Why read novels?

    Why should you read novels?

  20. They say you’re supposed to choose your prior in advance.

  21. When I started this blog, I promised myself that I would always steer into weirdness.

  22. That your dog, while she appears to love you only because she’s been adapted by evolution to appear to love you, really does love you.

  23. I recently asked why people seem to hate dating apps so much.

  24. Here are a few things that seem to be true: Dating apps are very popular.

  25. I recently wondered if explainer posts might go extinct.

  26. Will short-form non-fiction internet writing go extinct?

  27. Say an alien spaceship is headed for Earth.

  28. I fear we are in the waning days of the People Read Blog Posts About Random Well-Understood Topics Instead of Asking Their Automatons Era.

  29. Dear PendingKetchup

    PendingKetchup comments on my recent post on what it means for something to be heritable: The article seems pretty good at math and thinking through unusual implications, but my armchair Substack eugenics alarm that I keep in the back of my brain is beepi…

  30. Here’s one possible hobby: Take something you don’t like.

  31. Say I think abortion is wrong.