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If you have an injury or feel very ill most people don't bother thinking which specific hospital to visit or what doctor to see.

I used to think that you could love someone unconditionally or conditionally, and I never really thought that you could do both at the same time, but it just occurred to me today that this is indeed not only possible but advisable!

Dynomight on the rise of colorectal (and other types of) cancer in young people Writing is thinking: a case against using AI for writing Can you (if you are a worm, that is) acquire memories by eating them?

One morning I got a call from my younger brother Jaime.

Monoclonal antibodies against Abeta continue to have lackluster performance (I have a standing bet that this will continue) Rapamycin tested in a human clinical trial over 13 weeks on various strength endpoints, didn't work On Writing AI Constitutions Med…

I just recorded a new podcast you can find here.

The use of the Forced Perspective Technique in Lord of the Rings To my surprise, OpenAI seemingly didn't get their money back for GPT5's training if one includes the costs of running the org.

At a recent retreat, I found myself sitting on a cushion facing a wall while my meditation partner sat to my side, outside of my visual field and started reading to me "From You to Infinity", pointing-out instructions from Ken Wilber.

"The Claude Constitution is a beautiful document.

Since the recent disappointingly small effects of monoclonal antibodies on Alzheimer's Disease (AD) progression, there has been lots of discourse around what the cause of Alzheimer's might be.

Bacteria isolated from japanese tree frogs shown to work better in mice against cancer than doxorubicin or checkpoint inhibitors CAR-T to treat cardiovascular disease New proteomics clock, I wrote a brief thread with some commentary On the (deranged, imho)

Nasa's orion is flaming garbage Looks like the AI 2027 report scenario isn't happening and money is running out, fundraising is no longer enough, and large debt raises are now happening.

Book Review of Breakneck from Noah Smith, endorsed On China and rare earths Rotating detonation engines Progress in pan-cancer therapy DOGE and its consequences in the federal government The AI revolution in radiology that never was Pictures of the old and

I just turned 33 and thought: What are some lessons I keep coming back to?

One of the reasons I like living in the Bay Area are the social occasions one rarely finds anywhere else.

Two scientists may look at the same data and draw different conclusions.

What is aging and how to measure it is an everpresent question in the field of aging research.

Lithium orotate seems to help with Alzheimer's Electronics components have gotten very very cheap in the past few decades On LLM adoption from Zvi Mowshowitz On the wild stories where someone that gets an organ transplant sometimes experience personality…

Good post on what the meaning of heritability.

So I went down to the beach.

The term "agency" is popular these days.

Why Pantone colors are so expensive A while back Scott Alexander gave some grants.

Sasha Chapin on spiritual awakening Works in Progress links post 50 facts about construction Why aren't more companies working on atherosclerosis plaque removal?

Retinoids (retinoic acid, retinol, retinal, tretinoin, adapalene, etc) are commonly claimed to both revert and also slow down skin aging.

Why can't biology move faster?

Sasha Chapin on Enjoying Things and Being Sasha Chapin Scott Alexander reviews The Body keeps the Score.

There's this practice called Circling1 that I do sometimes.

An inside view via 19 cameras of the NYC restaurant Crown Shy (which I recommend, get the gruyere frites and the roasted short rib) Curtis Yarvin's recent interview [transcript].

First commercial-scale fusion plant plans announced, to be built in the early 2030s Roger Penrose's biography Renaissance Philantrophy (and within, a link to recent research on wearable cortisol trackers!)

Laura Deming on understanding Interesting uses of AI The memes of the wealthy Elon dreams and bitter lessons Nabeel on Palantir Scott reviews Deep Utopia Meditation, considered harmful There is no placebo effect Dwarkesh interviews Gwern Restoring fertili…

Lots of interest in gene editing startups but in practice they don't do that well: Few diseases can be corrected through gene editing, hence valuations of such companies, despite FDA approvals, are low.