ergosome

People (including me) usually come to DepMap for the synthetic lethalities, the strongly selective dependencies, and the extremely negative gene effect scores (often CERES/Chronos < -1) that scream “this gene is essential for this cell line”; but I have r…

Part I Part II Part III (you are reading this) If you have ever watched a crowd surge toward an emergency, sirens blaring and lights flashing, you have seen the good side of a fast response.

Part I Part II (you are reading this) Part III Your immune system is a powerful guard dog, but it needs training.

Part I (you are reading this) Part II Part III The adaptive immune system depends on a controlled act of genomic violence.

If you have ever heard p53 (a protein encoded by the TP53 gene) called “the guardian of the genome,” you might picture a wise molecular sentry that patrols DNA, stops cell cycles, and flips apoptosis switches like a seasoned air-traffic controller.

Akin to vibe coding, vibe researching is a modern approach to learning where you use LLMs to dive into a topic by prompting, exploring, and iterating—essentially ‘vibing’ your way through the research while the AI handles the deep reading and connects the…

On Nov 4, 2025, I received an e-mail from Claude letting me know that I’d been granted $1,000 in credits for the web-based Claude Code environment (https://claude.ai/code).

Interview Transcript Edited for clarity and readability Sander Wuyts: Hi everyone.

How adding a few dots and curves to letters became a 3.7‑million‑parameter adventure The “Simple” Problem Picture this: you’re reading Turkish text where someone forgot to add the special characters.

Given a software code repository together with all commit history, can you spot potentially problematic parts of the software?

In my earlier post, I talked about what it takes to apply to independent fellowship positions.

As I wrote earlier, I am interested in becoming an early independent fellow and started a blog series about it.

I am a fifth-year graduate student … and considering applying for such and such fellowships… So starts my e-mail messages to program coordinators nowadays.

The Dream Imagine a cancer patient walking into the clinic to learn her therapy options.

I do terrible when it comes to application for fellowships.

I love preprint services.

As I mentioned earlier, the data available as part of the Cancer Genome Atlas (TCGA) project is incredibly useful for many types of analysis.

Right after I came up with the μ-wheel visualization, people immediately followed up with the obvious question: “looks nice, but what is next?”

I am truly amazed by the abundance of the cancer genomics data and our current knowledge about the genes and the pathways they are involved in.

Hi there!